Intra-Workout Supplements Stimulates Muscle Protein Synthesis

Intra-Workout Supplements Stimulates Muscle Protein Synthesis

by: Robbie Durand

If your training hard, its important that you refuel your body with the right nutrients. There is a thin line between training hard and overtraining, but taking the right supplements can help you stay anabolic. A single session of resistance exercise has been suggested to stimulate muscle protein synthesis for up to 48 hours, however, in the absence of nutrient intake, net protein balance remains negative. There are some health advocates that still believe that carbs are “bad” and lead to weight gain. Studies on the impact of carbohydrate and protein ingestion on muscle protein synthesis have generally focused on nutrient intake during acute postexercise recovery.

Carbohydrate ingestion during postexercise recovery attenuates the exercise-induced increase in muscle protein breakdown but does not affect muscle protein synthesis. To get the maximal increases in muscle protein synthesis rate, It has been suggested that the ingestion of carbohydrate and protein before and/or after exercise inhibits protein breakdown and stimulates muscle protein synthesis, resulting in net muscle protein synthesis during recovery.

Most athletes consume their protein shakes after exercise but the new research suggests that it may be wise to consume a protein and carbohydrate beverage during exercise for maximal gains. The interesting finding of the study was that the athletes who trained during the evening in which most people train had a greater post-exercise protein synthesis level that night.

Researchers investigated the effect of carbohydrate and protein hydrolysate ingestion on whole-body and muscle protein synthesis during a combined endurance and resistance exercise session and subsequent overnight recovery. Twenty healthy men were studied in the evening after consuming a standardized diet throughout the day. Subjects participated in a 2-hour exercise session during which beverages containing both carbohydrate (0.15 grams per kg per hour) and a protein hydrolysate (0.15 grams per kg per hour) (C+P, n = 10) or water only were ingested. Participants consumed 2 additional beverages during early recovery and remained overnight at the hospital.

At the end of the study, The data show that, even in the fed state, supplementation with carbohydrate and a protein hydrolysate elevates muscle protein synthesis during exercise, but interestingly the researchers found that the ingestion of protein and carbohydrates does not further augment muscle protein synthesis over the subsequent overnight recovery period. The study shows that ingestion of carbohydrate and protein hydrolysate during a combined endurance and resistance exercise session stimulates both whole-body and skeletal muscle protein synthesis rates during exercise conditions. The present study indicates that it might be preferable to ingest carbohydrate and protein already during resistance exercise to further augment the skeletal muscle adaptive response to exercise training.

Carbohydrate and protein ingestion increased whole-body protein synthesis by 40% during the first 3 h of postexercise recovery compared with the water drinking control treatment. During subsequent overnight recovery, whole-body protein synthesis was 19% greater in the carbohydrates and protein group than in the water group.

The researchers concluded that, even in a fed state, protein and carbohydrate supplementation stimulates muscle protein synthesis during exercise. Ingestion of protein with carbohydrate during and immediately after exercise improves whole-body protein synthesis but does not further augment muscle protein synthesis rates during 9 hours of subsequent overnight recovery.

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