Infinite One Series: D-ASPARTIC ACID - Infinte Labs
Infinite One Series: D-ASPARTIC ACID - Infinte Labs

Infinite One Series: D-ASPARTIC ACID

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D-Aspartic Acid is an amino acid described as a neurotransmitter and a stimulant that acts as a regulator of testosterone synthesis.*




D-Aspartic Acid is found naturally in the testes, pituitary gland and hypothalamus, all of which are involved in hormone production. Aspartic acid comes in two forms, L and D. The l-aminos build tissue. But when l-aspartic acid combines with enzymes in the testes, it becomes a d-aspartic acid, which has been shown to support testosterone levels in the blood.*

D-Aspartic acid is an endogenous amino acid that has been found in the neuroendocrine tissues of both invertebrates and vertebrates. D-Aspartic acid can be used as a testosterone booster for infertile men, and by athletes as a temporary booster. D-Aspartic Acid is believed to stimulate the production and release of testosterone through multiple pathways.

• It has been shown to increase testosterone indirectly in rats by increasing steroidogenic acute regulatory protein (StAR) gene expression in testosterone producing Leydig cells. By increasing levels of StAR, D-Aspartic Acid may indirectly increase testosterone, as the transportation of cholesterol is believed to be the rate-limiting step in the production of testosterone.

• Test Tube studies performed on rats demonstrated that D-Aspartic Acid increased levels of testosterone. This is believed to occur due to the accumulation of D-Aspartic Acid in the anterior pituitary and testes.

Human studies on D-Aspartic Acid supplementation are sparse. One study with a small number of subjects demonstrated that after 12 days of D-Aspartic Acid supplementation, increased levels of testosterone by 42%. This study has been replicated by another study where 2.66g of D-aspartic acid was able to increase serum testosterone in infertile men by a variable 30-60% after 90 days.

Topo E, Soricelli A, D’Aniello A, Ronsini S, D’Aniello G: The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats. Reprod Biol Endocrinol 2009, 7.

Nagata Y, Homma H, Matsumoto M, Imai K. Stimulation of steroidogenic acute regulatory protein (StAR) gene expression by D-aspartate in rat Leydig cells. FEBS Lett. 1999; 454(3):317-20.

D’Aniello A, Di Fiore MM, Fisher GH, Milone A, Seleni A, D’Aniello S et al.. Occurrence of D-aspartic acid and N-methyl-D-aspartic acid in rat neuroendocrine tissues and their role in the modulation of luteinizing hormone and growth hormone release. FASEB J. 2000; 14(5):699-714.

Nagata Y, Homma H, Lee JA, Imai K. D-Aspartate stimulation of testosterone synthesis in rat Leydig cells. FEBS Lett. 1999; 444(2–3):160-4.

D’Aniello, Gemma, et al. “D-Aspartate, a Key Element for the Improvement of Sperm Quality.” Advances in Sexual Medicine 2.4 (2012): 45-53.


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