CLARINOL® CLA SUPPLEMENT
Table of Contents
ABOUT CLA SUPPLEMENT:
Clarinol® is a patented version of CLA (Conjugated Linoleic Acid), a component extracted from natural safflower oil that supports the fat burning process by targeting adipose tissue.* Clarinol is the best CLA Supplement by Infinite Labs till date.
Clarinol® CLA MAY HELP TO:
• SUPPORT THE FAT BURNING PROCESS*
• ASSIST WITH WEIGHT MANAGEMENT*
CLA, Conjugated Linoleic Acid is a blend of fatty acids comprised of the basic structure of linoleic acid (18 carbons with two double bonds). They are all polyunsaturated fatty acids, with some also being trans fatty acids. While many forms exist, there are two in particular that are most commonly referenced: c9t11 (cis-9, trans11) and t10c12 (trans-10, cis-12), classified after the location of the bonds on the side chain.* |
CLA has been shown to support fat reduction and overall health due to the effect it has on the molecular signaling receptor family known as PPAR, which is related to inflammation and lipid metabolism.*
Infinite One® CLA utilizes the patented version, Clarinol®, that is backed by scientific studies and clinical research. Supplementation ranges from 3 – 6.5 grams daily, typically consumed with meals. This dosage is based on the product being comprised of approximately 70% of one of the two main active isomers, cis-9 trans-11 (c9t11) and trans-10 cis-12 (t10c12).*
Conjugated linoleic acid (CLA) is a naturally occurring fatty acid that is found in beef (beef and lamb) and dairy products (milk and cheese). The CLA isomer that is involved in the body fat-lowering effect and active in lipid metabolism is the trans-10, cis-12 isomer, whereas > 90% of the total CLA intake from food in humans is accounted for by the cis-9, trans-11 isomer. CLA is a commercially available weight loss supplement that has been associated with a reduction in muscle glycogen breakdown, improved endurance capacity, reduced body mass and a decreases in muscle damage and inflammatory responses. It has been reported that CLA has anti-obesity potentials, such as reducing lipogenesis and food intake, and increasing energy expenditure, lipolysis, and fat oxidation.
Studies in both men and women that supplemented with CLA along with a standardized physical exercise protocol have shown effective in improving endurance performance and body composition. There have been eight clinical trials that have shown positive reductions in body fat with CLA supplementation. Although there are many suspected mechanisms for fat loss with CLA, it seems the main reason is that CLA inhibits the activity of the enzyme lipoprotein lipase (LPL). This enzyme transfers fats from the bloodstream to the fat cells. As a result of the decreased enzyme activity, the transport of fat into fat cells is blocked.
At the same time, CLA also stimulates the breakdown of stored body fat (lipolysis); additional studies have shown that CLA increases the disintegration of cells (apoptosis), resulting in a decreased number of existing fat cells. A 2007 study from the University of Wisconsin-Madison confirmed that CLA supplementation increased calorie and fat burning during the night by almost 15% as compared to the control group. Over time, the small increase in fat burning that occurs during sleep can lead to a significant loss of body fat.
- Jeukendrup A.E., Aldred S. Fat supplementation, health, and endurance performance. Nutrition. 2004;20:678–688.
2. MacDonald H.B. Conjugated linoleic acid and disease prevention: A review of current knowledge. J. Am. Coll. Nutr. 2000;19:111S–118.
3. Wang Y.W., Jones P.J. Conjugated linoleic acid and obesity control: Efficacy and mechanisms. Int. J. Obes. Relat. Metab. Disord. 2004;28:941–955
4. Zambell K.L., Keim N.L., Van Loan M.D., Gale B., Benito P., Kelley D.S., Nelson G.J. Conjugated linoleic acid supplementation in humans: Effects on body composition and energy expenditure. Lipids.
5. Thom E., Wadstein J., Gudmundsen O. Conjugated linoleic acid reduces body fat in healthy exercising humans. J. Int. Med. Res. 2001;29:392–396.
6. Colakoglu S., Colakoglu M., Taneli F., Cetinoz F., Turkmen M. Cumulative effects of conjugated linoleic acid and exercise on endurance development, body composition, serum leptin and insulin levels. J. Sports Med. Phys. Fitness. 2006;46:570–577.
7. 29. Pinkoski C., Chilibeck P.D., Candow D.G., Esliger D., Ewaschuk J.B., Facci M., Farthing J.P., Zello G.A. The effects of conjugated linoleic acid supplementation during resistance training. Med. Sci. Sports Exerc. 2006;38:339–348.
8. Bruckner G., Webb P., Greenwell L., Chow C., Richardson D. Fish oil increases peripheral capillary blood cell velocity in humans. Atherosclerosis. 1987;66:237–245.
9. Macaluso F, Barone R, Catanese P, Carini F, Rizzuto L, Farina F, Di Felice V. Do fat supplements increase physical performance? Nutrients. 2013 Feb 7;5(2):509-24. doi: 10.3390/nu5020509. Review.
10. H. Blankson, J. A. Stakkestad, H. Fagertun, E. Thom, J. Wadstein, and O. Gudmundsen, “Conjugated linoleic acid reduces body fat mass in overweight and obese humans,” Journal of Nutrition, vol. 130, no. 12, pp. 2943–2948, 2000.
11. Whigham LD, Watras AC, Schoeller DA. Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. Am J Clin Nutr. 2007 May;85(5):1203-11.
12. Blankson H, Stakkestad JA, Fagerton H, Thom E, Wadstein J, Gudmundsen O. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J Nutr 2000;130:2943–8.
13. Gaullier JM, Halse J, Hoye K, et al. Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. Am J Clin Nutr 2004;79:1118–25.
14. Mougios V, Matsakas A, Petridou A, et al. Effect of supplementation with conjugated linoleic acid on human serum lipids and body fat. J Nutr Biochem 2001;12:585–94.
15. Smedman A, Vessby B. Conjugated linoleic acid supplementation in humans–metabolic effects. Lipids 2001;36:773–81.
16. Gaullier JM, Halse J, Høivik HO, et al. Six months supplementation with conjugated linoleic acid (CLA) induces regional-specific fat mass decreases in overweight and obese. Br J Nutr 2007;97:50–60.
17. Watras AC, Buchholz AC, Close RN, Zhang Z, Schoeller DA. The role of conjugated linoleic acid in reducing body fat and preventing holiday weight gain. Int J Obesity 2007;31:481–7.